High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes. [electronic resource]
Producer: 20140507Description: 1816-28 p. digitalISSN:- 1549-4918
- Animals
- Cell Line
- Disease Models, Animal
- Embryonic Stem Cells -- cytology
- Gene Expression Regulation -- drug effects
- Genes, Reporter
- High-Throughput Screening Assays -- methods
- Humans
- Huntington Disease -- pathology
- Luciferases -- metabolism
- Male
- Mice
- Mice, Inbred C57BL
- Neural Stem Cells -- cytology
- Neurons -- drug effects
- Repressor Proteins -- antagonists & inhibitors
- Small Molecule Libraries -- pharmacology
- Transcriptome -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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