The anticancer effect of cytotoxin 1 from Naja atra Cantor venom is mediated by a lysosomal cell death pathway involving lysosomal membrane permeabilization and cathepsin B release. [electronic resource]
Producer: 20131017Description: 643-63 p. digitalISSN:- 1793-6853
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Cathepsin B -- metabolism
- Cell Line, Tumor
- Cell Survival -- drug effects
- Cyclophosphamide -- pharmacology
- Dose-Response Relationship, Drug
- Elapid Venoms -- chemistry
- Elapidae
- Humans
- Intracellular Membranes -- drug effects
- K562 Cells
- Leukemia P388 -- drug therapy
- Lysosomes -- drug effects
- MCF-7 Cells
- Male
- Membrane Potential, Mitochondrial -- drug effects
- Mice
- Mice, Inbred Strains
- Mitochondria -- drug effects
- Neoplasms -- drug therapy
- Permeability
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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