Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway. [electronic resource]
Producer: 20131023Description: e646 p. digitalISSN:- 2041-4889
- Calcium -- metabolism
- Calcium-Binding Proteins -- metabolism
- Caspases -- metabolism
- Cell Line
- Cell Survival -- drug effects
- Gene Expression Regulation -- drug effects
- Humans
- Huntingtin Protein
- Mitochondria -- drug effects
- Morpholines -- pharmacology
- NF-kappa B -- metabolism
- Nerve Tissue Proteins -- genetics
- Reactive Oxygen Species -- metabolism
- Receptors, sigma -- agonists
- Signal Transduction -- drug effects
- Transcription Factor RelA -- metabolism
- Sigma-1 Receptor
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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