Optimization of triazine nitriles as rhodesain inhibitors: structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L. [electronic resource]
Producer: 20140123Description: 967-75 p. digitalISSN:- 1860-7187
- Cathepsin L -- chemistry
- Crystallography, X-Ray
- Cysteine Endopeptidases -- metabolism
- Cysteine Proteinase Inhibitors -- chemical synthesis
- Dose-Response Relationship, Drug
- Humans
- Imidazoles -- chemical synthesis
- Ligands
- Models, Molecular
- Molecular Structure
- Nitriles -- chemical synthesis
- Parasitic Sensitivity Tests
- Pyridines -- chemical synthesis
- Structure-Activity Relationship
- Triazines -- chemical synthesis
- Trypanosoma brucei brucei -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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