In Silico screening on the three-dimensional model of the Plasmodium vivax SUB1 protease leads to the validation of a novel anti-parasite compound. [electronic resource]
Producer: 20130906Description: 18561-73 p. digitalISSN:- 1083-351X
- Amino Acid Sequence
- Animals
- Antimalarials -- chemistry
- Binding Sites -- genetics
- Biocatalysis -- drug effects
- Dose-Response Relationship, Drug
- Erythrocytes -- drug effects
- Female
- Kinetics
- Malaria -- parasitology
- Merozoites -- drug effects
- Mice
- Models, Molecular
- Molecular Sequence Data
- Molecular Structure
- Plasmodium berghei -- drug effects
- Plasmodium vivax -- drug effects
- Protein Structure, Tertiary
- Protozoan Proteins -- chemistry
- Sequence Homology, Amino Acid
- Serine Proteases -- chemistry
- Serine Proteinase Inhibitors -- chemistry
- Sf9 Cells
- Substrate Specificity
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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