Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis. [electronic resource]
Producer: 20131126Description: 568-78 p. digitalISSN:- 1476-5586
- Adenosine Triphosphate -- metabolism
- Aniline Compounds -- pharmacology
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Cell Line
- Dynamins
- GTP Phosphohydrolases -- metabolism
- Gossypol -- analogs & derivatives
- Humans
- Membrane Potential, Mitochondrial -- drug effects
- Mice
- Microtubule-Associated Proteins -- metabolism
- Mitochondria -- drug effects
- Mitochondrial Dynamics -- drug effects
- Mitochondrial Proteins -- metabolism
- Myeloid Cell Leukemia Sequence 1 Protein -- antagonists & inhibitors
- Reactive Oxygen Species -- metabolism
- Sulfonamides -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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