Benzo[a]pyrene affects Jurkat T cells in the activated state via the antioxidant response element dependent Nrf2 pathway leading to decreased IL-2 secretion and redirecting glutamine metabolism. [electronic resource]
Producer: 20130717Description: 307-16 p. digitalISSN:- 1096-0333
- Basic Helix-Loop-Helix Transcription Factors -- drug effects
- Benzo(a)pyrene -- pharmacology
- Blotting, Western
- Enzyme-Linked Immunosorbent Assay
- Glutamine -- metabolism
- Humans
- Interleukin-2 -- biosynthesis
- Jurkat Cells -- drug effects
- NF-E2-Related Factor 2 -- physiology
- Receptors, Aryl Hydrocarbon -- drug effects
- Signal Transduction -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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