ASS1 as a novel tumor suppressor gene in myxofibrosarcomas: aberrant loss via epigenetic DNA methylation confers aggressive phenotypes, negative prognostic impact, and therapeutic relevance. [electronic resource]
Producer: 20140108Description: 2861-72 p. digitalISSN:- 1557-3265
- Adult
- Aged
- Amino-Acid N-Acetyltransferase -- biosynthesis
- Animals
- Argininosuccinate Synthase -- deficiency
- Cell Line, Tumor
- Cell Movement -- genetics
- Cell Proliferation
- Cell Survival -- drug effects
- Cluster Analysis
- DNA Methylation
- Female
- Fibrosarcoma -- drug therapy
- G1 Phase Cell Cycle Checkpoints -- genetics
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Gene Knockdown Techniques
- Genes, Tumor Suppressor
- Humans
- Hydrolases -- administration & dosage
- Leiomyosarcoma -- drug therapy
- Male
- Mice
- Middle Aged
- Neoplasm Grading
- Neoplasm Invasiveness
- Neoplasm Staging
- Neovascularization, Pathologic -- genetics
- Phenotype
- Polyethylene Glycols -- administration & dosage
- Prognosis
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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