Immune suppression in cynomolgus monkeys by XPro9523: an improved CTLA4-Ig fusion with enhanced binding to CD80, CD86 and neonatal Fc receptor FcRn. [electronic resource]
Producer: 20150416Description: 384-96 p. digitalISSN:- 1942-0870
- Abatacept
- Animals
- Antibody Affinity
- Antibody Formation -- drug effects
- Arthritis, Experimental -- therapy
- Arthritis, Rheumatoid -- therapy
- B7-1 Antigen -- immunology
- B7-2 Antigen -- immunology
- Cells, Cultured
- Female
- Graft Rejection -- therapy
- Histocompatibility Antigens Class I -- immunology
- Humans
- Immunoconjugates -- genetics
- Immunosuppression Therapy
- Kidney Transplantation
- Lymphocyte Activation -- drug effects
- Macaca fascicularis
- Male
- Mice
- Mice, Inbred DBA
- Mutation -- genetics
- Protein Binding -- drug effects
- Protein Engineering
- Receptors, Fc -- immunology
- Recombinant Fusion Proteins -- genetics
- Structure-Activity Relationship
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Publication Type: Journal Article
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