Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319. [electronic resource]
Producer: 20131227Description: e58575 p. digitalISSN:- 1932-6203
- 3T3 Cells
- Amino Acid Substitution
- Animals
- Cell Line
- Drug Design
- Fibroblast Growth Factors -- chemistry
- Gene Expression
- Genetic Variation
- Hep G2 Cells
- Humans
- Klotho Proteins
- Male
- Membrane Proteins -- metabolism
- Mice
- Models, Molecular
- Pichia -- genetics
- Protein Conformation
- Protein Stability
- Recombinant Proteins
- Temperature
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Publication Type: Journal Article
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