A synthetic dolastatin 10 analogue suppresses microtubule dynamics, inhibits cell proliferation, and induces apoptotic cell death. [electronic resource]
Producer: 20130523Description: 2235-45 p. digitalISSN:- 1520-4804
- Antineoplastic Agents -- chemical synthesis
- Apoptosis -- drug effects
- Caspase 3 -- metabolism
- Cell Proliferation -- drug effects
- Colchicine -- pharmacology
- Depsipeptides -- chemical synthesis
- Drug Interactions
- Drug Resistance, Neoplasm -- drug effects
- GTP Phosphohydrolases -- metabolism
- HeLa Cells
- Humans
- JNK Mitogen-Activated Protein Kinases -- metabolism
- Kinetochores -- drug effects
- MCF-7 Cells
- Microtubules -- drug effects
- Mitosis -- drug effects
- Protein Multimerization -- drug effects
- Protein Structure, Quaternary
- Tubulin -- chemistry
- Vinblastine -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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