Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. [electronic resource]
Producer: 20131111Description: 1972-80 p. digitalISSN:- 1557-3265
- Adenocarcinoma -- drug therapy
- Animals
- Apoptosis -- drug effects
- Basic Helix-Loop-Helix Transcription Factors -- genetics
- Cell Cycle -- drug effects
- Cell Line, Tumor
- Cyclic S-Oxides -- pharmacology
- Flow Cytometry
- Gene Expression Regulation, Neoplastic
- Green Fluorescent Proteins -- genetics
- Homeodomain Proteins -- genetics
- Humans
- Immunohistochemistry
- Kaplan-Meier Estimate
- Lung Neoplasms -- drug therapy
- Mice
- Mice, Inbred NOD
- Mice, Nude
- Mice, SCID
- Multivariate Analysis
- Neoplastic Stem Cells -- drug effects
- Protein Isoforms -- antagonists & inhibitors
- Receptors, Notch -- antagonists & inhibitors
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction -- drug effects
- Thiadiazoles -- pharmacology
- Transcription Factor HES-1
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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