A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling. [electronic resource]
Producer: 20130523Description: 2619-29 p. digitalISSN:- 1520-4804
- Amino Acid Sequence
- Antineoplastic Agents -- metabolism
- Cell Line, Tumor
- Crystallography, X-Ray
- Drug Approval
- Fungal Proteins
- Genomics
- Humans
- Ligands
- Mitogen-Activated Protein Kinases -- antagonists & inhibitors
- Mitoxantrone -- metabolism
- Molecular Docking Simulation
- Protein Conformation
- Protein Kinase Inhibitors -- metabolism
- Substrate Specificity
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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