Cinnamaldehyde-induced apoptosis in human hepatoma PLC/PRF/5 cells involves the mitochondrial death pathway and is sensitive to inhibition by cyclosporin A and z-VAD-fmk. [electronic resource]
Producer: 20140725Description: 1565-74 p. digitalISSN:- 1875-5992
- Acrolein -- analogs & derivatives
- Amino Acid Chloromethyl Ketones -- pharmacology
- Antineoplastic Agents, Phytogenic -- pharmacology
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins
- Caspase 3 -- genetics
- Cell Line, Tumor
- Cyclosporine -- pharmacology
- Cytochromes c -- metabolism
- Gene Expression Regulation, Neoplastic
- Hepatocytes -- drug effects
- Humans
- Intracellular Signaling Peptides and Proteins -- genetics
- Mitochondria -- drug effects
- Mitochondrial Membrane Transport Proteins -- genetics
- Mitochondrial Permeability Transition Pore
- Mitochondrial Proteins -- genetics
- Poly(ADP-ribose) Polymerases -- genetics
- Reactive Oxygen Species -- metabolism
- Signal Transduction
- X-Linked Inhibitor of Apoptosis Protein -- genetics
- bcl-2-Associated X Protein -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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