Development of targeting lonidamine liposomes that circumvent drug-resistant cancer by acting on mitochondrial signaling pathways. [electronic resource]
Producer: 20130814Description: 3366-80 p. digitalISSN:- 1878-5905
- Adenosine Triphosphate -- metabolism
- Animals
- Antineoplastic Agents -- pharmacology
- Caspases -- metabolism
- Cell Death -- drug effects
- Cell Line, Tumor
- Cell Survival -- drug effects
- Cytochromes c -- metabolism
- Drug Delivery Systems
- Drug Resistance, Neoplasm -- drug effects
- Enzyme Activation -- drug effects
- Epirubicin -- pharmacology
- Female
- Humans
- Indazoles -- pharmacology
- Liposomes -- chemistry
- Membrane Potential, Mitochondrial -- drug effects
- Mice
- Mice, Inbred BALB C
- Mitochondria -- drug effects
- Myeloid Cell Leukemia Sequence 1 Protein
- Neoplasms -- drug therapy
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Reactive Oxygen Species -- metabolism
- Signal Transduction -- drug effects
- Xenograft Model Antitumor Assays
- bcl-2-Associated X Protein -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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