Regulatory effect of calcineurin inhibitor, tacrolimus, on IL-6/sIL-6R-mediated RANKL expression through JAK2-STAT3-SOCS3 signaling pathway in fibroblast-like synoviocytes. [electronic resource]
Producer: 20150512Description: R26 p. digitalISSN:- 1478-6362
- Animals
- Arthritis, Experimental -- drug therapy
- Arthritis, Rheumatoid -- immunology
- Blotting, Western
- Calcineurin Inhibitors -- pharmacology
- Cells, Cultured
- Enzyme-Linked Immunosorbent Assay
- Female
- Fibroblasts -- drug effects
- Humans
- Interleukin-6 -- immunology
- Janus Kinase 2 -- metabolism
- Male
- Mesenchymal Stem Cells -- drug effects
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- RANK Ligand -- biosynthesis
- Real-Time Polymerase Chain Reaction
- STAT3 Transcription Factor -- metabolism
- Signal Transduction -- drug effects
- Suppressor of Cytokine Signaling 3 Protein
- Suppressor of Cytokine Signaling Proteins -- metabolism
- Synovial Membrane -- cytology
- Tacrolimus -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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