Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-anti-trypsin deficiency. [electronic resource]
Producer: 20130722Description: 397-412 p. digitalISSN:- 1757-4684
- Animals
- Apoptosis
- Autophagy -- genetics
- Autophagy-Related Protein 7
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors -- genetics
- Disease Models, Animal
- Gene Transfer Techniques
- Genetic Predisposition to Disease
- Genetic Therapy -- methods
- HeLa Cells
- Humans
- Interleukin-6 -- metabolism
- Liver -- enzymology
- Liver Cirrhosis -- genetics
- Lysosomes -- metabolism
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Microtubule-Associated Proteins -- deficiency
- Mutation, Missense
- NF-kappa B -- metabolism
- Papio
- Phenotype
- Time Factors
- Transfection
- alpha 1-Antitrypsin -- genetics
- alpha 1-Antitrypsin Deficiency -- complications
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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