Phosphorylation of eIF2α attenuates statin-induced apoptosis by inhibiting the stabilization and translocation of p53 to the mitochondria. [electronic resource]
Producer: 20130716Description: 810-6 p. digitalISSN:- 1791-2423
- Animals
- Anthracenes -- pharmacology
- Anticholesteremic Agents -- pharmacology
- Apoptosis -- drug effects
- Cell Line, Tumor
- Cell Survival -- drug effects
- Cinnamates -- pharmacology
- Endoplasmic Reticulum -- drug effects
- Endoplasmic Reticulum Chaperone BiP
- Endoplasmic Reticulum Stress -- drug effects
- Eukaryotic Initiation Factor-2 -- genetics
- Fibrosarcoma
- Heat-Shock Proteins -- biosynthesis
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacology
- JNK Mitogen-Activated Protein Kinases -- antagonists & inhibitors
- Membrane Potential, Mitochondrial -- drug effects
- Mevalonic Acid -- pharmacology
- Mice
- Mitochondria -- drug effects
- Phosphorylation
- Polyisoprenyl Phosphates -- pharmacology
- Protein Transport -- drug effects
- RNA Interference
- RNA, Small Interfering
- Sesquiterpenes -- pharmacology
- Signal Transduction -- drug effects
- Simvastatin -- pharmacology
- Thiourea -- analogs & derivatives
- Transcription Factor CHOP -- biosynthesis
- Tumor Suppressor Protein p53 -- metabolism
- bcl-2-Associated X Protein -- metabolism
- eIF-2 Kinase -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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