LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. [electronic resource]
Producer: 20130404Description: 143-58 p. digitalISSN:- 1878-3686
- AMP-Activated Protein Kinases -- genetics
- Animals
- Apoptosis -- drug effects
- Blotting, Western
- Carcinoma, Non-Small-Cell Lung -- drug therapy
- Cell Proliferation -- drug effects
- Cells, Cultured
- Eukaryotic Initiation Factor-2 -- genetics
- Humans
- Hypoglycemic Agents -- therapeutic use
- Lung Neoplasms -- drug therapy
- Mice
- Mice, Knockout
- Mitochondria -- drug effects
- Mutation -- genetics
- Phenformin -- therapeutic use
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins p21(ras) -- physiology
- RNA, Messenger -- genetics
- Real-Time Polymerase Chain Reaction
- Reverse Transcriptase Polymerase Chain Reaction
- Tumor Suppressor Protein p53 -- physiology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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