Anti-tumour efficacy on glioma models of PHA-848125, a multi-kinase inhibitor able to cross the blood-brain barrier. [electronic resource]
Producer: 20140905Description: 156-66 p. digitalISSN:- 1476-5381
- Animals
- Antineoplastic Agents -- pharmacokinetics
- Blood-Brain Barrier -- metabolism
- Brain Neoplasms -- drug therapy
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Combined Modality Therapy
- Dacarbazine -- analogs & derivatives
- Drug Synergism
- Glioma -- drug therapy
- Humans
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Protein Kinase Inhibitors -- pharmacokinetics
- Pyrazoles -- pharmacokinetics
- Quinazolines -- pharmacokinetics
- Rats
- Rats, Sprague-Dawley
- Signal Transduction -- drug effects
- Temozolomide
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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