DNA sequence variants in PPARGC1A, a gene encoding a coactivator of the ω-3 LCPUFA sensing PPAR-RXR transcription complex, are associated with NV AMD and AMD-associated loci in genes of complement and VEGF signaling pathways. [electronic resource]
Producer: 20130627Description: e53155 p. digitalISSN:- 1932-6203
- Aged
- Aged, 80 and over
- Animals
- Cohort Studies
- Complement System Proteins -- genetics
- Fatty Acids, Omega-3 -- metabolism
- Female
- Gene Expression Profiling
- Gene Regulatory Networks
- Heat-Shock Proteins -- chemistry
- Humans
- Macular Degeneration -- genetics
- Male
- Mice
- Neovascularization, Pathologic -- genetics
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
- Polymorphism, Single Nucleotide
- Retina -- metabolism
- Signal Transduction
- Transcription Factors -- chemistry
- Vascular Endothelial Growth Factor A -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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