Pharmacokinetics, metabolism, and excretion of the glycogen synthase kinase-3 inhibitor LY2090314 in rats, dogs, and humans: a case study in rapid clearance by extensive metabolism with low circulating metabolite exposure. [electronic resource]
Producer: 20131104Description: 714-26 p. digitalISSN:- 1521-009X
- Animals
- Antineoplastic Agents -- metabolism
- Bile -- metabolism
- Dogs
- Feces -- chemistry
- Glycogen Synthase Kinase 3 -- antagonists & inhibitors
- Glycogen Synthase Kinase 3 beta
- Heterocyclic Compounds, 3-Ring -- pharmacokinetics
- Humans
- Male
- Maleimides -- pharmacokinetics
- Microsomes, Liver -- metabolism
- Protein Kinase Inhibitors -- metabolism
- Rats
- Urine -- chemistry
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Publication Type: Clinical Trial, Phase I; Comparative Study; Journal Article; Multicenter Study
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