Proteolysis breaks tolerance toward intact α345(IV) collagen, eliciting novel anti-glomerular basement membrane autoantibodies specific for α345NC1 hexamers. [electronic resource]
Producer: 20130328Description: 1424-32 p. digitalISSN:- 1550-6606
- Animals
- Anti-Glomerular Basement Membrane Disease -- genetics
- Antibody Specificity
- Autoantibodies -- biosynthesis
- Autoantigens -- immunology
- Collagen Type IV -- immunology
- Disease Models, Animal
- Epitopes -- immunology
- Female
- HEK293 Cells
- Humans
- Immune Tolerance -- genetics
- Immunoglobulin G -- biosynthesis
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mice, Knockout
- Mice, Transgenic
- Proteolysis
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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