Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma. [electronic resource]
Producer: 20130705Description: 1847-57 p. digitalISSN:- 1527-3350
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Benzylidene Compounds -- pharmacology
- Carcinoma, Hepatocellular -- drug therapy
- Cell Line, Tumor
- Cell Movement -- drug effects
- Cell Survival -- drug effects
- Drug Resistance, Neoplasm -- drug effects
- Drug Therapy, Combination
- Humans
- Hypoxia -- physiopathology
- Hypoxia-Inducible Factor 1, alpha Subunit -- antagonists & inhibitors
- Liver Neoplasms -- drug therapy
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- NF-kappa B -- metabolism
- Niacinamide -- analogs & derivatives
- Phenylurea Compounds -- pharmacology
- Piperidones -- pharmacology
- Sorafenib
- Treatment Outcome
- Von Hippel-Lindau Tumor Suppressor Protein -- metabolism
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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