Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells. [electronic resource]
Producer: 20130610Description: e51735 p. digitalISSN:- 1932-6203
- Adaptor Proteins, Signal Transducing -- metabolism
- Carrier Proteins -- metabolism
- Cell Cycle Proteins
- Cell Line, Tumor
- Endoplasmic Reticulum Chaperone BiP
- Gene Silencing
- Heat-Shock Proteins -- genetics
- Humans
- Low Density Lipoprotein Receptor-Related Protein-1 -- metabolism
- Male
- Mechanistic Target of Rapamycin Complex 1
- Mechanistic Target of Rapamycin Complex 2
- Models, Biological
- Monomeric GTP-Binding Proteins -- metabolism
- Multiprotein Complexes -- metabolism
- Neuropeptides -- metabolism
- Phosphoproteins -- metabolism
- Phosphorylation -- drug effects
- Prostatic Neoplasms -- genetics
- Protein Binding
- Protein Biosynthesis
- Proto-Oncogene Proteins c-akt -- metabolism
- RNA Interference
- Rapamycin-Insensitive Companion of mTOR Protein
- Ras Homolog Enriched in Brain Protein
- Regulatory-Associated Protein of mTOR
- Ribosomal Protein S6 Kinases -- metabolism
- Signal Transduction
- TOR Serine-Threonine Kinases -- metabolism
- Tuberous Sclerosis Complex 2 Protein
- Tumor Suppressor Proteins -- metabolism
- alpha-Macroglobulins -- metabolism
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Publication Type: Journal Article
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