Targeted disruption of the p160 coactivator interface of androgen receptor (AR) selectively inhibits AR activity in both androgen-dependent and castration-resistant AR-expressing prostate cancer cells. [electronic resource]
Producer: 20130829Description: 763-72 p. digitalISSN:- 1878-5875
- Androgen Receptor Antagonists -- chemistry
- Androgens -- metabolism
- Animals
- Binding Sites -- drug effects
- COS Cells
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Chlorocebus aethiops
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Male
- Molecular Targeted Therapy
- Nuclear Receptor Coactivators -- chemistry
- Peptide Fragments -- chemistry
- Prostate-Specific Antigen -- antagonists & inhibitors
- Prostatic Neoplasms -- pathology
- Protein Structure, Tertiary
- Receptors, Androgen -- genetics
- Transcriptional Activation -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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