Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule secretion in platelets. [electronic resource]
Producer: 20130419Description: 3918-28 p. digitalISSN:- 1083-351X
- Amino Acid Substitution
- Animals
- Blood Platelets -- metabolism
- Fibrinogen -- metabolism
- Glycogen Synthase Kinase 3 -- antagonists & inhibitors
- Glycogen Synthase Kinase 3 beta
- Heterocyclic Compounds, 3-Ring -- pharmacology
- Mice
- Mice, Knockout
- Mutation, Missense
- P-Selectin -- biosynthesis
- Phosphorylation -- drug effects
- Platelet Aggregation -- drug effects
- Platelet Glycoprotein GPIIb-IIIa Complex -- genetics
- Protein Kinase C-alpha -- genetics
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- Pyridines -- pharmacology
- Pyrimidines -- pharmacology
- Secretory Vesicles -- genetics
- Thrombin -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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