Phase 1 and phase 2 drug metabolism and bile acid production of HepaRG cells in a bioartificial liver in absence of dimethyl sulfoxide. [electronic resource]
Producer: 20130712Description: 562-7 p. digitalISSN:- 1521-009X
- Aryl Hydrocarbon Hydroxylases -- metabolism
- Bile Acids and Salts -- metabolism
- Bilirubin -- metabolism
- Bioreactors
- Biotransformation
- Cell Culture Techniques
- Cell Line
- Cytochrome P-450 CYP2C9
- Cytochrome P-450 CYP3A -- metabolism
- Dimethyl Sulfoxide -- pharmacology
- Glucuronosyltransferase -- metabolism
- Hepatocytes -- drug effects
- Humans
- Hydroxylation
- Isoenzymes
- Kinetics
- Liver, Artificial
- Metabolic Detoxication, Phase I
- Metabolic Detoxication, Phase II
- Rifampin -- pharmacology
- Substrate Specificity
- Testosterone
- Tolbutamide -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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