The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia. [electronic resource]
Producer: 20130321Description: 628-37 p. digitalISSN:- 1528-0020
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Antineoplastic Agents -- pharmacokinetics
- Benzamides
- Cell Line, Tumor
- Female
- Gene Expression
- Gene Expression Regulation, Leukemic
- Genotype
- Humans
- Imatinib Mesylate
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- drug therapy
- Male
- Middle Aged
- Models, Molecular
- Organic Cation Transporter 1 -- chemistry
- Piperazines -- pharmacokinetics
- Polymorphism, Single Nucleotide
- Protein Conformation
- Protein Kinase Inhibitors -- pharmacokinetics
- Pyrimidines -- pharmacokinetics
- Treatment Outcome
- Young Adult
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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