Fragment-based discovery of novel and selective mPGES-1 inhibitors Part 1: identification of sulfonamido-1,2,3-triazole-4,5-dicarboxylic acid. [electronic resource]
Producer: 20130528Description: 75-80 p. digitalISSN:- 1464-3405
- Binding Sites
- Catalytic Domain
- Crystallography, X-Ray
- Dicarboxylic Acids -- chemical synthesis
- Drug Design
- Drug Evaluation, Preclinical
- Enzyme Inhibitors -- chemical synthesis
- Humans
- Intramolecular Oxidoreductases -- antagonists & inhibitors
- Microsomes -- enzymology
- Molecular Docking Simulation
- Prostaglandin-E Synthases
- Protein Binding
- Sulfonamides -- chemical synthesis
- Thermodynamics
- Triazoles -- chemical synthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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