Concurrent inhibition of PI3-kinase and mTOR induces cell death in diffuse large B cell lymphomas, a mechanism involving down regulation of Mcl-1. [electronic resource]
Producer: 20131108Description: 288-97 p. digitalISSN:- 1872-7980
- Adaptor Proteins, Signal Transducing -- metabolism
- Cell Cycle Checkpoints -- drug effects
- Cell Cycle Proteins
- Cell Death -- genetics
- Cell Line, Tumor
- Everolimus
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Imidazoles -- pharmacology
- Lymphoma, Large B-Cell, Diffuse -- genetics
- Myeloid Cell Leukemia Sequence 1 Protein
- NF-kappa B -- metabolism
- Phosphatidylinositol 3-Kinase -- metabolism
- Phosphoinositide-3 Kinase Inhibitors
- Phosphoproteins -- metabolism
- Phosphorylation
- Proto-Oncogene Proteins c-akt -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- Proto-Oncogene Proteins c-pim-1 -- metabolism
- Quinolines -- pharmacology
- RNA Interference
- Ribosomal Protein S6 Kinases, 70-kDa -- metabolism
- Signal Transduction
- Sirolimus -- analogs & derivatives
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
No physical items for this record
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
There are no comments on this title.
Log in to your account to post a comment.