Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence. [electronic resource]
Producer: 20130606Description: 149-66 p. digitalISSN:- 1757-4684
- Animals
- Antineoplastic Agents -- pharmacology
- Ataxia Telangiectasia Mutated Proteins
- Aurora Kinases
- Azepines -- pharmacology
- Benzazepines -- pharmacology
- Cell Cycle Proteins -- metabolism
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cellular Senescence -- drug effects
- Checkpoint Kinase 2
- DNA Damage
- DNA-Binding Proteins -- metabolism
- Humans
- Melanoma, Experimental -- drug therapy
- Mice
- Mice, Nude
- NF-kappa B -- antagonists & inhibitors
- Polyploidy
- Protein Kinase Inhibitors -- pharmacology
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Pyrimidines -- pharmacology
- Tumor Suppressor Protein p53 -- metabolism
- Tumor Suppressor Proteins -- metabolism
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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