Severe growth deficiency is associated with STAT5b mutations that disrupt protein folding and activity. [electronic resource]
Producer: 20130607Description: 150-61 p. digitalISSN:- 1944-9917
- Animals
- Base Sequence
- COS Cells
- Cell Nucleus -- metabolism
- Chlorocebus aethiops
- Growth Disorders -- genetics
- Growth Hormone -- physiology
- Humans
- Mice
- Models, Molecular
- Mutation, Missense
- Phosphorylation
- Protein Binding
- Protein Folding
- Protein Processing, Post-Translational
- Protein Stability
- Protein Structure, Quaternary
- Protein Structure, Secondary
- Protein Transport
- Rats
- Receptors, Somatotropin -- metabolism
- STAT5 Transcription Factor -- chemistry
- Structural Homology, Protein
- Thermodynamics
- Transcriptional Activation
- src Homology Domains
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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