Glucagon-like peptide-1 receptor agonist inhibits asymmetric dimethylarginine generation in the kidney of streptozotocin-induced diabetic rats by blocking advanced glycation end product-induced protein arginine methyltranferase-1 expression. [electronic resource]
Producer: 20130606Description: 132-41 p. digitalISSN:- 1525-2191
- Animals
- Arginine -- analogs & derivatives
- Diabetes Mellitus, Experimental -- drug therapy
- Diabetic Nephropathies -- drug therapy
- Drug Evaluation, Preclinical -- methods
- Exenatide
- Gene Expression Regulation, Enzymologic -- drug effects
- Glucagon-Like Peptide 1 -- pharmacology
- Glucagon-Like Peptide-1 Receptor
- Glycation End Products, Advanced -- physiology
- Humans
- Hypertrophy -- prevention & control
- Hypoglycemic Agents -- pharmacology
- Kidney -- metabolism
- Kidney Glomerulus -- pathology
- Kidney Tubules -- metabolism
- Macrophages -- pathology
- Male
- Peptides -- pharmacology
- Protein-Arginine N-Methyltransferases -- biosynthesis
- RNA, Messenger -- genetics
- Rats
- Rats, Wistar
- Reactive Oxygen Species -- metabolism
- Receptor for Advanced Glycation End Products
- Receptors, Glucagon -- agonists
- Receptors, Immunologic -- metabolism
- Repressor Proteins -- biosynthesis
- Venoms -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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