The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosis via mitochondrial-lysosomal cross-talk. [electronic resource]
Producer: 20130528Description: 2682-93 p. digitalISSN:- 1097-0215
- Antimalarials -- pharmacology
- Apoptosis -- drug effects
- Autophagy
- Blotting, Western
- Cell Membrane Permeability -- drug effects
- Chloroquine -- pharmacology
- Drug Synergism
- Enzyme Inhibitors -- pharmacology
- Humans
- Imidazoles -- pharmacology
- Immunoprecipitation
- Lysosomes -- drug effects
- Membrane Potential, Mitochondrial -- drug effects
- Mitochondria -- drug effects
- Neuroblastoma -- drug therapy
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphoinositide-3 Kinase Inhibitors
- Proto-Oncogene Proteins c-akt -- metabolism
- Quinolines -- pharmacology
- Reactive Oxygen Species -- metabolism
- Signal Transduction -- drug effects
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Tumor Cells, Cultured
- bcl-2-Associated X Protein -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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