Targeting CXCR1/2 significantly reduces breast cancer stem cell activity and increases the efficacy of inhibiting HER2 via HER2-dependent and -independent mechanisms. [electronic resource]
Producer: 20130715Description: 643-56 p. digitalISSN:- 1557-3265
- Breast Neoplasms -- genetics
- Cell Line, Tumor
- ErbB Receptors -- antagonists & inhibitors
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Interleukin-8 -- metabolism
- Neoplasm Grading
- Neoplasm Metastasis
- Neoplastic Stem Cells -- metabolism
- RNA Interference
- Receptor, ErbB-2 -- antagonists & inhibitors
- Receptors, Interleukin-8A -- antagonists & inhibitors
- Receptors, Interleukin-8B -- antagonists & inhibitors
- Signal Transduction
- Spheroids, Cellular
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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