Cancer-associated somatic DICER1 hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage. [electronic resource]
Producer: 20130319Description: 400-9 p. digitalISSN:- 1096-9896
- Animals
- DEAD-box RNA Helicases -- genetics
- DNA Mutational Analysis
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Mice
- MicroRNAs -- genetics
- Mutation
- Ovarian Neoplasms -- genetics
- RNA Processing, Post-Transcriptional -- physiology
- RNA, Messenger -- metabolism
- RNA, Small Interfering -- metabolism
- Ribonuclease III -- genetics
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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