Lenalidomide-mediated enhanced translation of C/EBPα-p30 protein up-regulates expression of the antileukemic microRNA-181a in acute myeloid leukemia. [electronic resource]
Producer: 20130225Description: 159-69 p. digitalISSN:- 1528-0020
- Adult
- Animals
- Antimetabolites, Antineoplastic -- pharmacology
- CCAAT-Enhancer-Binding Proteins -- biosynthesis
- Cell Line, Tumor -- drug effects
- Cytarabine -- pharmacology
- Frameshift Mutation
- Gene Expression Regulation, Leukemic -- drug effects
- Humans
- Immunologic Factors -- pharmacology
- K562 Cells
- Lenalidomide
- Leukemia, Myeloid, Acute -- drug therapy
- Mice
- Mice, Inbred NOD
- Mice, SCID
- MicroRNAs -- biosynthesis
- Neoplasm Proteins -- biosynthesis
- Point Mutation
- Promoter Regions, Genetic -- genetics
- Protein Isoforms -- biosynthesis
- Protein Structure, Tertiary
- RNA, Neoplasm -- biosynthesis
- Recombinant Fusion Proteins -- physiology
- Thalidomide -- analogs & derivatives
- Up-Regulation -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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