STAT1 activation by venous malformations mutant Tie2-R849W antagonizes VEGF-A-mediated angiogenic response partly via reduced bFGF production. [electronic resource]
Producer: 20130530Description: 207-22 p. digitalISSN:- 1573-7209
- Base Sequence
- Cell Movement -- drug effects
- Cell Nucleus -- drug effects
- Endothelial Cells -- metabolism
- Fibroblast Growth Factor 2 -- biosynthesis
- Human Umbilical Vein Endothelial Cells -- drug effects
- Humans
- Molecular Sequence Data
- Mutation, Missense -- genetics
- Myocytes, Smooth Muscle -- drug effects
- Neovascularization, Physiologic -- drug effects
- Neutralization Tests
- Phosphorylation -- drug effects
- Phosphotyrosine -- metabolism
- Promoter Regions, Genetic -- genetics
- Protein Binding -- drug effects
- Protein Transport -- drug effects
- Receptor, TIE-2 -- genetics
- STAT1 Transcription Factor -- metabolism
- STAT3 Transcription Factor -- metabolism
- Vascular Endothelial Growth Factor A -- pharmacology
- Vascular Malformations -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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