MK-0448, a specific Kv1.5 inhibitor: safety, pharmacokinetics, and pharmacodynamic electrophysiology in experimental animal models and humans. [electronic resource]
Producer: 20130226Description: 1193-201 p. digitalISSN:- 1941-3084
- Adult
- Animals
- Atrial Fibrillation -- physiopathology
- Delayed Rectifier Potassium Channels -- antagonists & inhibitors
- Disease Models, Animal
- Dogs
- Dose-Response Relationship, Drug
- Double-Blind Method
- Electrophysiological Phenomena -- drug effects
- Female
- Heart Conduction System -- physiology
- Heart Failure -- physiopathology
- Humans
- In Vitro Techniques
- Kv1.5 Potassium Channel -- antagonists & inhibitors
- Male
- Potassium Channel Blockers -- adverse effects
- Pyridines -- adverse effects
- Sinoatrial Node -- physiology
- Sulfonamides -- adverse effects
- Vagus Nerve -- physiology
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Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
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