A novel small molecule FL118 that selectively inhibits survivin, Mcl-1, XIAP and cIAP2 in a p53-independent manner, shows superior antitumor activity. [electronic resource]
Producer: 20130306Description: e45571 p. digitalISSN:- 1932-6203
- Animals
- Antineoplastic Agents -- chemistry
- Apoptosis -- drug effects
- Benzodioxoles -- chemistry
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- DNA Topoisomerases, Type I -- metabolism
- Drug Screening Assays, Antitumor
- Female
- Gene Expression Regulation, Neoplastic -- drug effects
- High-Throughput Screening Assays
- Humans
- Indolizines -- chemistry
- Inhibitor of Apoptosis Proteins -- antagonists & inhibitors
- Maximum Tolerated Dose
- Mice
- Mice, Nude
- Mice, SCID
- Myeloid Cell Leukemia Sequence 1 Protein
- Neoplasms -- drug therapy
- Promoter Regions, Genetic -- drug effects
- Proto-Oncogene Proteins c-bcl-2 -- antagonists & inhibitors
- Survivin
- Tumor Burden -- drug effects
- Tumor Suppressor Protein p53 -- genetics
- X-Linked Inhibitor of Apoptosis Protein -- antagonists & inhibitors
- Xenograft Model Antitumor Assays
No physical items for this record
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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