Autoinhibition of CYP3A4 leads to important role of CYP2C8 in imatinib metabolism: variability in CYP2C8 activity may alter plasma concentrations and response. [electronic resource]
Producer: 20130625Description: 50-9 p. digitalISSN:- 1521-009X
- Antineoplastic Agents -- blood
- Aryl Hydrocarbon Hydroxylases -- metabolism
- Benzamides -- blood
- Cytochrome P-450 CYP2C8
- Cytochrome P-450 CYP3A -- metabolism
- Cytochrome P-450 CYP3A Inhibitors
- Humans
- Imatinib Mesylate
- Microsomes, Liver -- enzymology
- Piperazines -- blood
- Pyrimidines -- blood
- Recombinant Proteins -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Study
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