Gemcitabine reactivates epigenetically silenced genes and functions as a DNA methyltransferase inhibitor. [electronic resource]
Producer: 20130528Description: 1505-11 p. digitalISSN:- 1791-244X
- Antimetabolites, Antineoplastic -- pharmacology
- Azacitidine -- analogs & derivatives
- Cell Line, Tumor
- CpG Islands
- DNA (Cytosine-5-)-Methyltransferase 1
- DNA (Cytosine-5-)-Methyltransferases -- antagonists & inhibitors
- DNA Methylation
- Decitabine
- Deoxycytidine -- analogs & derivatives
- Enzyme Stability
- Epigenesis, Genetic
- Gene Expression Regulation, Neoplastic -- drug effects
- Gene Silencing
- Histone Deacetylase 1 -- metabolism
- Humans
- Promoter Regions, Genetic
- Tumor Suppressor Proteins -- genetics
- Vascular Endothelial Growth Factor Receptor-1 -- genetics
- Gemcitabine
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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