Prolonged exposure to methylglyoxal causes disruption of vascular KATP channel by mRNA instability. [electronic resource]
Producer: 20130122Description: C1045-54 p. digitalISSN:- 1522-1563
- ATP-Binding Cassette Transporters -- genetics
- Animals
- Cloning, Molecular
- Gene Expression Regulation -- drug effects
- HEK293 Cells
- Humans
- KATP Channels -- genetics
- Mesenteric Arteries -- drug effects
- Patch-Clamp Techniques
- Potassium Channels, Inwardly Rectifying -- genetics
- Pyruvaldehyde -- toxicity
- RNA Stability -- drug effects
- RNA, Messenger -- genetics
- Rats
- Rats, Sprague-Dawley
- Real-Time Polymerase Chain Reaction
- Receptors, Drug -- genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Sulfonylurea Receptors
- Vasoconstriction -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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