Synthetic lethal screening with small-molecule inhibitors provides a pathway to rational combination therapies for melanoma. [electronic resource]
Producer: 20130423Description: 2505-15 p. digitalISSN:- 1538-8514
- Antineoplastic Agents -- analysis
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Cell Death -- drug effects
- Cell Line, Tumor
- Diclofenac -- pharmacology
- Drug Synergism
- Extracellular Signal-Regulated MAP Kinases -- antagonists & inhibitors
- Gene Expression Regulation, Neoplastic -- drug effects
- Genome, Human -- genetics
- Humans
- Melanoma -- drug therapy
- Niacinamide -- analogs & derivatives
- Phenylurea Compounds -- pharmacology
- Phospholipases A2, Cytosolic -- metabolism
- Signal Transduction -- drug effects
- Skin Neoplasms -- drug therapy
- Small Molecule Libraries -- analysis
- Sorafenib
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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