mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis. [electronic resource]
Producer: 20130529Description: 401-14 p. digitalISSN:- 1875-9777
- Animals
- Carcinoma, Squamous Cell -- enzymology
- Cell Compartmentation -- drug effects
- Cell Death -- drug effects
- Cell Proliferation -- drug effects
- Cells, Cultured
- Cellular Senescence -- drug effects
- Clone Cells
- Cytoprotection -- drug effects
- Epithelial Cells -- drug effects
- Head and Neck Neoplasms -- enzymology
- Humans
- Keratinocytes -- drug effects
- Mice
- Mouth Mucosa -- drug effects
- Mucositis -- enzymology
- Oxidative Stress -- drug effects
- Radiation Injuries -- enzymology
- Radiation, Ionizing
- Sirolimus -- pharmacology
- Stem Cells -- drug effects
- Superoxide Dismutase -- metabolism
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
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