IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice. [electronic resource]
Producer: 20130201Description: 3476-89 p. digitalISSN:- 1558-8238
- Animals
- Carrier Proteins -- biosynthesis
- Caspase 1 -- physiology
- Chemokine CCL2 -- biosynthesis
- Drug Evaluation, Preclinical
- Ethanol -- toxicity
- Fatty Liver, Alcoholic -- drug therapy
- Female
- Hepatocytes -- metabolism
- Inflammasomes -- physiology
- Interleukin 1 Receptor Antagonist Protein -- therapeutic use
- Interleukin-1alpha -- biosynthesis
- Interleukin-1beta -- biosynthesis
- Kupffer Cells -- pathology
- Liver Cirrhosis -- etiology
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- NLR Family, Pyrin Domain-Containing 3 Protein
- Receptors, Interleukin-1 Type I -- deficiency
- Recombinant Proteins -- therapeutic use
- Signal Transduction -- drug effects
- Toll-Like Receptor 4 -- physiology
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Review
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