Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner. [electronic resource]
Producer: 20130107Description: 36639-49 p. digitalISSN:- 1083-351X
- Adenosine Triphosphate -- chemistry
- Aminophenols -- chemistry
- Animals
- Caprylates -- chemistry
- Cell Line
- Chromatography, Affinity
- Cystic Fibrosis Transmembrane Conductance Regulator -- chemistry
- Detergents -- chemistry
- Fluorocarbons -- chemistry
- Humans
- Ion Channel Gating -- drug effects
- Liposomes
- Mutant Proteins -- chemistry
- Mutation, Missense
- Phosphorylation
- Protein Binding
- Protein Conformation -- drug effects
- Protein Processing, Post-Translational
- Quinolones -- chemistry
- Sequence Deletion
- Signal Transduction -- drug effects
- Spodoptera
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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