Inhibition of sumoylation prevents experimental fibrosis. [electronic resource]
Producer: 20121220Description: 1904-8 p. digitalISSN:- 1468-2060
- Adolescent
- Adult
- Animals
- Disease Models, Animal
- Female
- Fibroblasts -- drug effects
- Fibrosis -- prevention & control
- Gene Knockdown Techniques
- Humans
- Immunosuppressive Agents -- therapeutic use
- Keratinocytes -- metabolism
- Male
- Methotrexate -- therapeutic use
- Mice
- Middle Aged
- RNA, Small Interfering -- genetics
- Receptors, Transforming Growth Factor beta -- metabolism
- SUMO-1 Protein -- genetics
- Scleroderma, Systemic -- metabolism
- Signal Transduction
- Skin -- pathology
- Smad3 Protein -- metabolism
- Sumoylation -- physiology
- Ubiquitin-Conjugating Enzymes -- genetics
- Young Adult
- Ubiquitin-Conjugating Enzyme UBC9
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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