Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction. [electronic resource]
Producer: 20130104Description: 5961-5 p. digitalISSN:- 1464-3405
- Antineoplastic Agents -- chemistry
- Apoptosis Regulatory Proteins -- antagonists & inhibitors
- Bcl-2-Like Protein 11
- Cell Proliferation -- drug effects
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- Enzyme-Linked Immunosorbent Assay
- Humans
- Membrane Proteins -- antagonists & inhibitors
- Models, Molecular
- Molecular Conformation
- Myeloid Cell Leukemia Sequence 1 Protein
- Naphthalenes -- chemical synthesis
- Protein Binding -- drug effects
- Proto-Oncogene Proteins -- antagonists & inhibitors
- Proto-Oncogene Proteins c-bcl-2 -- antagonists & inhibitors
- Structure-Activity Relationship
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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